کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10582546 | 981052 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and anti-HCMV activity of 1-[Ï-(phenoxy)alkyl]uracil derivatives and analogues thereof
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and anti-HCMV activity of 1-[Ï-(phenoxy)alkyl]uracil derivatives and analogues thereof Synthesis and anti-HCMV activity of 1-[Ï-(phenoxy)alkyl]uracil derivatives and analogues thereof](/preview/png/10582546.png)
چکیده انگلیسی
HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[Ï-(phenoxy)alkyl]uracil derivatives were synthesized and examined for antiviral properties. Compounds 17, 20, 24 and 28 were found to exhibit highly specific and promising inhibitory activity against HCMV replication in HEL cell cultures with EC50 values within 5.5-12 μM range. Further studies should be undertaken to elucidate the mechanism of action of these compounds and the structure-activity relationship for the linker region.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 14, 15 July 2013, Pages 4151-4157
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 14, 15 July 2013, Pages 4151-4157
نویسندگان
Mikhail S. Novikov, Denis A. Babkov, Maria P. Paramonova, Anastasia L. Khandazhinskaya, Alexander A. Ozerov, Alexander O. Chizhov, Graciela Andrei, Robert Snoeck, Jan Balzarini, Katherine L. Seley-Radtke,