کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10582571 | 981052 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
6â²-Methyl-5â²-homoaristeromycin: A structural variation of the anti-orthopox virus candidate 5â²-homoaristeromycin
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
The synthesis of 6â²-methyl-5â²-homoaristeromycin is described from a known 6â²-ethyl ester. Antiviral analysis showed the (S)-6â² stereoisomer retained the vaccinia activity of the parent 5â²-homoaristeromycin (1) while the (R)-6â² isomer was less active. Both were weaker than 1 towards cowpox. The diastereomers were equally active versus Epstein Barr virus while (S)-6â² was three times more active toward vesicular stomatitis virus than (R)-6â². The diastereomers were inactive towards numerous other viruses. The CC50 for both diastereomers was >300 μM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 14, 15 July 2013, Pages 4374-4377
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 14, 15 July 2013, Pages 4374-4377
نویسندگان
Minmin Yang, Wei Ye, Stewart W. Schneller,