کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10582573 | 981052 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antibacterial activity of novel phosphonium salts on the basis of pyridoxine
ترجمه فارسی عنوان
سنتز و فعالیت ضد میکروبی نمک های جدید فسفونیوم بر پایه پیریدوکسین
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کلمات کلیدی
نمک فسفونیوم کواترنر، پیریدوکسین، فعالیت ضد باکتری،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
A series of 13 phosphonium salts on the basis of pyridoxine derivatives were synthesized and their antibacterial activity against clinically relevant strains was tested in vitro. All compounds were almost inactive against gram-negative bacteria and exhibited structure-dependent activity against gram-positive bacteria. A crucial role of ketal protection group in phosphonium salts for their antibacterial properties was demonstrated. Among synthesized compounds 5,6-bis[triphenylphosphonio(methyl)]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine dichloride (compound 20) was found to be the most effective towards Staphylococcus aureus and Staphylococcus epidermidis strains (MIC 5 μg/ml). The mechanism of antibacterial activity of this compound probably involves cell penetration and interaction with genomic and plasmid DNA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 14, 15 July 2013, Pages 4388-4395
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 14, 15 July 2013, Pages 4388-4395
نویسندگان
Mikhail V. Pugachev, Nikita V. Shtyrlin, Lubov P. Sysoeva, Elena V. Nikitina, Timur I. Abdullin, Alfiya G. Iksanova, Alina A. Ilaeva, Rashid Z. Musin, Eugeny A. Berdnikov, Yurii G. Shtyrlin,