کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10582585 | 981060 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The antitumor agent doxorubicin binds to Fanconi anemia group F protein
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Doxorubicin, a commonly used cancer chemotherapy agent, elicits several potent biological effects, including synergistic-antitumor activity in combination with cisplatin. However, the mechanism of this synergism remains obscure. Here, we employed an improved T7 phage display screening method to identify Fanconi anemia group F protein (FANCF) as a doxorubicin-binding protein. The FANCF-doxorubicin interaction was confirmed by pull-down assay and SPR analysis. FANCF is a component of the Fanconi anemia complex, which monoubiquitinates D2 protein of Fanconi anemia group as a cellular response against DNA cross-linkers such as cisplatin. We observed that the monoubiquitination was inhibited by doxorubicin treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 21, 1 November 2012, Pages 6248-6255
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 21, 1 November 2012, Pages 6248-6255
نویسندگان
Tomoe Kusayanagi, Senko Tsukuda, Satomi Shimura, Daisuke Manita, Kanako Iwakiri, Shinji Kamisuki, Yoichi Takakusagi, Toshifumi Takeuchi, Kouji Kuramochi, Atsuo Nakazaki, Kengo Sakaguchi, Susumu Kobayashi, Fumio Sugawara,