LuxR dependent quorum sensing inhibition by N,N′-disubstituted imidazolium salts

N,N′-Disubstituted imidazolium salts have been prepared and tested as LuxR dependent quorum sensing inhibitors. Some of them displayed IC50 in the micromolar range. These results suggest that a disubstituted imidazolium ring may be considered as a new pharmacophore for QS inhibition.