Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: Synthesis, binding affinity and intrinsic activity for MT1 and MT2 melatonin receptors

New dimeric melatonin receptor ligands with different bridging position and spacer length were synthesized and evaluated in vitro for their binding affinity and intrinsic activity at h-MT1 and h-MT2 receptors.