Cytotoxicity of new polyfluorinated 1,4-naphtoquinones with diverse substituents in the quinone moiety

Eight new derivatives of polyfluoro-l,4-naphthoquinonc were synthesized and their cytotoxicity in human myeloma (RPMI 8226), human mammary adenocarcinoma (MCF-7), mouse fibroblasts (LMTK), and primary mouse fibroblast cells (PMF) were studied. It was shown that average efficiency of suppressing of two lines of tumor cells decrease from 1 to 8 compound and all compounds are less toxic toward LMTK and PMF cells.