3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the α2-adrenoceptor compared to the imidazoline I1 receptor

3[(Imidazolidin-2-yl)imino]indazole derivatives 4a-k were synthesized as positional analogues of marsanidine. Compound 4d proved to be partial α2-adrenoceptor agonist with high α2-adrenoceptor selectivity relative to the imidazoline I1 receptor and was shown to possess pronounced hypotensive activity.