Synthesis, in vitro and in vivo preliminary evaluation of anti-angiogenic properties of some pyrroloazaflavones

Pyrroloazaflavones or 2-phenyl-1H-pyrrolo[2,3-h]quinolin-4(7H)-ones show in vitro and in vivo anti-angiogenic activity and counteract the pro-angiogenic effects of FGF-2 at non-cytotoxic concentrations.