Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones

IC50 values of pseudohypericin (4.40 μM) towards TrxR1 is noticeably higher than that of hypericin (157.08 μM), in accordance with the modeling results. IC50 values measured towards TrxR2 were 7.45 μM for pseudohypericin and 43.12 μM for hypericin.