Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3

Eleven 2-aminobenzaldehyde oxime analogs were synthesized. Of these, 6 had the potential to inhibit the activities of neutrophil elastase and proteinase 3. In addition, it also reduce paw edema induced by LPS and HNE, as well as acute lung injury. Therefore, 6 may be approved as a candidate for the development of new agents in the treatment of neutrophilic inflammatory diseases.