Discovery of a novel class anti-proliferative agents and potential inhibitors of EGFR tyrosine kinases based on 4-anilinotetrahydropyrido[4,3-d]pyrimidine scaffold: Design, synthesis and biological evaluations

The discovery of 4-anilinotetrahydropyrido[4,3-d]pyrimidines as the novel anti-proliferative agents and EGFR kinase inhibitors were reported.100