Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sit

Non-conserved serine residues within H-bond distance of a 2-carboxyethylphenylalanine-derivative in GluK1 binding pocket. The hydrophobic surfaces with an isovalue of -0.5 kcal/mol is shown in yellow.