کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10584010 981314 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel benzopolycyclic amines with NMDA receptor antagonist activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel benzopolycyclic amines with NMDA receptor antagonist activity
چکیده انگلیسی
A new series of benzopolycyclic amines active as NMDA receptor antagonists were synthesized. Most of them exhibited increased activity compared with related analogues previously published. All the tested compounds were more potent than clinically approved amantadine and one of them displayed a lower IC50 value than memantine, an anti-Alzheimer's approved drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 22, Issue 9, 1 May 2014, Pages 2678-2683
نویسندگان
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