Design, synthesis and ex-vivo release studies of colon-specific polyphosphazene-anticancer drug conjugates

The ex-vivo release profile of polyphosphazene drug conjugates (11-18) was performed with or without rat cecal content. The results showed that polymer drug conjugates having n-butanol as a more lipohillic moiety (14 and 18) attached to the polymeric backbone having more than 89% of drug release from polymeric backbone.