کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10584974 981356 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase
چکیده انگلیسی
N-Acylethanolamines (NAEs) including N-arachidonoylethanolamine (anandamide) and N-palmitoylethanolamine are endogenous lipid mediators. These molecules are degraded to the corresponding fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH) or NAE-hydrolyzing acid amidase (NAAA). Lipophilic amines, especially pentadecylamine (2c) and tridecyl 2-aminoacetate (11b), were found to exhibit potent NAAA inhibitory activities (IC50 = 5.7 and 11.8 μM), with much weaker effects on FAAH. These simple structures would provide a scaffold for further improvement in NAAA inhibitory activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 11, 1 June 2012, Pages 3658-3665
نویسندگان
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