Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents

The synthesis and pharmacology of 1-alkyl-3-(4-halo-1-naphthoyl)indoles and 1-alkyl-3-(8-halo-1-naphthoyl)indoles (R = C3H7 and C5H11, R′ = H and CH3) is described. Three of these compounds have useful selectivity for the CB2 receptor.