Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs

A new class of co-drugs obtained by joining antioxidant edaravone with a vasodilating substructure containing NO-donor functions, is presented. These compounds, characterized by a good gastrointestinal absorption, afford edaravone and the related NO-donor moieties when incubated in human serum and in rat liver homogenate. The title products are potentially useful for treating ROS-related conditions accompanied by decreased NO availability.