Modification of HIV-1 reverse transcriptase and integrase activity by gold(III) complexes in direct biochemical assays

Schematic model of HIV-1 reverse transcriptase (RT) illustrating the positions of cysteine residues (in yellow) and methionine residues (in orange). In this manuscript, gold(III) compounds are shown to reduce HIV-1 RT activity, potentially though the oxidation of these residues.