Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2′-deoxyuridines

A series of novel C-5 benzimidazolyl-2′-deoxyuridines was synthesized in good yields under solvent-free conditions and microwave irradiation from 5-formyl-2′-deoxyuridine and arylenediamine derivatives in the presence of NaHSO3 as catalyst. Their absorption and fluorescence spectra were measured. They showed intense fluorescence around 400-500 nm with quantum yields between 0.3 and 0.5. All compounds studied in this work were screened for their antibacterial activities against a series of Gram positive and negative bacteria. The trifluoromethyl substituted benzimidazole derivatives showed some antibacterial activity.