کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10585505 981367 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thioglycine and l-thiovaline: Biologically active H2S-donors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Thioglycine and l-thiovaline: Biologically active H2S-donors
چکیده انگلیسی
Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H2S donors hold promise as novel treatments for cardiovascular diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 8, 15 April 2012, Pages 2675-2678
نویسندگان
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