Design, synthesis and CoMFA studies of N1-amino acid substituted 2,4,5-triphenyl imidazoline derivatives as p53-MDM2 binding inhibitors

Twenty-three novel N1-amino-acid substituted 2,4,5-triphenyl imidazoline derivatives were designed and synthesized as p53-MDM2 binding inhibitors. And statistically significant CoMFA model with high predict abilities was established.