Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group

A series of (4-piperidinyl)-piperazine derivatives having a novel fluorine substituted tert-butoxycarbonyl (F-Boc) group was identified as potent ACC1/2 non-selective inhibitors.