Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides

A series of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides were prepared and evaluated for their inhibitory activity against human cytochrome P450C24A1 (CYP24A1) hydroxylase. The styryl derivative (11c) displayed enhanced activity (IC50 = 0.3 μM) compared with the standard ketoconazole, providing a useful lead.