Synthesis and antiproliferative evaluation of certain iminonaphtho[2,3-b]furan derivatives

(Z)-4-Methoxyiminonaphtho[2,3-b]furan-9(4H)-one (9) exhibited a GI50 value of 0.60 μM against the growth of K562 cells and was inactive against the normal fibroblast Detroit 551. The selectivity index (SI) on K562 cell for 9 was >166.67 which is comparable to daunorubicin (SI = 239) and is more favorable than camptothecin (SI = 16.5).