New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase-Discovery of a new polyhydroxylated antiviral agent

A series of 13 hydroxylated 2-arylnaphthalenes has been synthesized and evaluated as HIV-1 integrase inhibitors. 7-(3,4,5-Trihydroxyphenyl)naphthalene-1,2,3-triol was converted to a dimer. This dimer displays submicromolar activity against HIV-1 IN and was found to present antiviral properties with a low cytotoxicity on two different cell lines.