Synthesis and cytotoxic activity of a new potential DNA bisintercalator: 1,4-Bis{3-[N-(4-chlorobenzo[g]phthalazin-1-yl)aminopropyl]}piperazine

The synthesis of new 1,4-bis(alkylamino)- and 1-alkylamino-4-chloro-benzo[g]phtalazine derivatives is reported, and the in vitro activity of their mono- or diprotonated forms against human colon, breast and lung carcinoma cells, and also against human glioblastoma cells is tested.