کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10586404 981390 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C4-Alkylthiols with activity against Moraxella catarrhalis and Mycobacterium tuberculosis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
C4-Alkylthiols with activity against Moraxella catarrhalis and Mycobacterium tuberculosis
چکیده انگلیسی
Antimicrobial resistance represents a global threat to healthcare. The ability to adequately treat infectious diseases is increasingly under siege due to the emergence of drug-resistant microorganisms. New approaches to drug development are especially needed to target organisms that exhibit broad antibiotic resistance due to expression of β-lactamases which is the most common mechanism by which bacteria become resistant to β-lactam antibiotics. We designed and synthesized 20 novel monocyclic β-lactams with alkyl- and aryl-thio moieties at C4, and subsequently tested these for antibacterial activity. These compounds demonstrated intrinsic activity against serine β-lactamase producing Mycobacterium tuberculosis wild type strain (Mtb) and multiple (n = 6) β-lactamase producing Moraxella catarrhalis clinical isolates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 22, 15 November 2011, Pages 6842-6852
نویسندگان
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