Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists

The pharmacophore model (Hypo1) for CysLT1 antagonists was developed. Virtual screening against an in-house database using Hypo1 was performed. Retrieved hits 26a,b and 27a,b were synthesized and biological evaluated for their CysLT1 antagonistic activities.