Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease

Dual-target-directed 1,3-diphenylurea derivatives were designed by hybridizing BACE 1 inhibitor 1 with metal chelator LR-90. Eleven compounds with favorable Fitvalues were selected, synthesized and evaluated for their BACE 1 inhibitory activities and the ability to function as metal chelators.