Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents

Eight tacrine-flurbiprofen-nitrate trihybrids were synthesized and biologically evaluated and most of them exhibited good performance. Particularly, compound 3a showed higher in vitro activity (Ki for AChE = 16.1 nM; Ki for BuChE = 1.7 nM) and lower hepatotoxicity than tacrine.