Bisaryldiketene derivatives: A new class of selective ligands for c-myc G-quadruplex DNA

A series of bisaryldiketene derivatives were designed and synthesized as a new class of specific G-quadruplex ligands. The primary binding affinity of ligand M2 for c-myc G-quadruplex DNA was over 200 times larger than that for telomere G-quadruplex DNA.