کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10587054 | 981414 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
N6-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
A series of adenosine analogues differently substituted in N6-position were synthesized to continue our studies on the relationships between structure and biological activity of iPA. The structures of the compounds were confirmed by standard studies of 1H NMR, MS and elemental analysis. These molecules were then evaluated for their anti-proliferative activity on bladder cancer cells. We found that some of these compounds possess anti-proliferative activity but have no effect on cell invasion and metalloprotease activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 23, 1 December 2010, Pages 8396-8402
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 23, 1 December 2010, Pages 8396-8402
نویسندگان
Roberta Ottria, Silvana Casati, Erika Baldoli, Jeanette A.M. Maier, Pierangela Ciuffreda,