کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10587206 981425 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New retinoid derivatives as back-ups of Adarotene
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
New retinoid derivatives as back-ups of Adarotene
چکیده انگلیسی
Adarotene belongs to the so-called class of atypical retinoids. The presence of the phenolic hydroxyl group on Adarotene structure allows a rapid O-glucuronidation as a major mechanism of elimination of the drug, favoring a fast excretion of its glucuronide metabolite in the urines. A series of ether, carbamate and ester derivatives was synthesized. All of them were studied and evaluated for their stability at different pH. The cytotoxic activity in vitro on NCI-H460 non-small cell lung carcinoma and A2780 ovarian tumor cell lines was also tested. A potential back-up of Adarotene has been selected to be evaluated in tumor models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 7, 1 April 2012, Pages 2405-2415
نویسندگان
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