Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A2A receptor antagonists

Novel thiazolotriazolopyrimidine derivatives were (23-33) designed and synthesized to evaluate their potential adenosine A2A receptor (A2AR) antagonists activity. Docking simulation results showed that thiazolotriazolopyrimidine derivatives (23-33) and SCH58261, a standard A2AR antagonist shared a similar binding motif inside the transmembrane (TM) region and extracellular loops of the human A2AR Our results showed that the compound 25 (R = C4H9) possessed reasonably good affinity (Ki = 0.12 nM) and high selectivity with A2A receptor (A2A/A1 = 1288).