Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors

Eighteen new pyridopyrazine and pyrimidothiazine derivatives were synthesized and tested against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H37Ra and Mtb H37Rv. Two compounds were studied in vivo in a murine Mtb model.