کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10587826 | 981440 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents](/preview/png/10587826.png)
چکیده انگلیسی
A new series of 1,3-biarylsulfanyl derivatives (homodibenzyl core motif) have been designed and synthesized as new estrogen receptor ligands by chopping benzothiophene core of raloxifene to engender seco-raloxifene scaffold. All the synthesized compounds were screened for anti-proliferative, anti-osteoporotic, and anti-implantation activity. Compounds (35, 36) having basic amino anti-estrogenic side chain were exhibiting potential anti-proliferative activity in MCF-7, MDA-MB-231 and ishikawa cell lines. Some of the synthesized compounds having homodibenzyl motif (5, 8, 10) have shown moderate anti-osteoporotic activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 18, 15 September 2011, Pages 5409-5419
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 18, 15 September 2011, Pages 5409-5419
نویسندگان
Atul Kumar, Vishwa Deepak Tripathi, Promod Kumar, Lalit Prakash Gupta, Akanksha Akanksha, Ritu Trivedi, Hemant Bid, V.L. Nayak, Jawed A. Siddiqui, Bandana Chakravarti, Ruchi Saxena, Anila Dwivedi, M.I. Siddiquee, U. Siddiqui, Rituraj Konwar,