Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes

In this work libraries of morpholines and oxazepanes have been prepared via the reductive amination reaction between dialdehydes, derived from carbohydrates, and a range of amines. The inhibitory profiles of these targets against a range of glycosidase enzymes have been assessed. Good inhibition of the β-d-galactosidase enzyme derived from Bovine kidney was obtained for a range of the morpholine targets.