کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10587911 | 981444 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Natural products inspired synthesis of neuroprotective agents against H2O2-induced cell death
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کلمات کلیدی
Oak Ridge thermal ellipsoid plotORTEPFDAm-CPBANOEHRMSAISTLCGSHnuclear magnetic resonance - رزونانس مغناطیسی هستهایROS - ROSrt-PA - RT-PAOxidative damage - آسیب اکسیداتیوnuclear overhauser effect - اثر بیش از حد هسته ایmeta-Chloroperoxybenzoic acid - اسید متاکلوپرکسیبنزوئیکNMR - تشدید مغناطیسی هستهای Intravenous - داخل وریدیFood and Drug Administration - سازمان غذا و داروStroke - سکته مغزیacute ischemic stroke - سکته مغزی ایسکمیک حادHigh resolution mass spectrometry - طیف سنجی جرمی با وضوح بالاNeuroprotective agents - عوامل ضد عفونیNatural products - فرآورده های طبیعیinorganic phosphate - فسفات معدنیRecombinant tissue plasminogen activator - فعال کننده پلاسمینوژن بافت بازمیگرددthin layer chromatography - کروماتوگرافی لایه نازکGlutathione - گلوتاتیونReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Stroke is a debilitating disease and the third leading cause of death in the USA, where over 2000 new stroke cases are diagnosed every day. Treatment options for stroke-related brain damage are very limited and there is an urgent need for effective neuroprotective agents to treat these conditions. Comparison of the structures of several classes of neuroprotective natural products such as limonoids and cardiac glycosides revealed the presence of a common structural motif which may account for their observed neuroprotective activity. Several natural product mimics that incorporate this shared structural motif were synthesized and were found to possess significant neuroprotective activity. These compounds enhanced cell viability against H2O2 induced oxidative stress or cell death in PC12 neuronal cells. The compounds were also found to enhance and modulate Na+/K+-ATPase activity of PC12 cells, which may suggest that the observed neuroprotective activity is mediated, at least partly, through interaction with Na+/K+-ATPase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 5, 1 March 2013, Pages 1232-1237
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 5, 1 March 2013, Pages 1232-1237
نویسندگان
Jehad Almaliti, Shadia E. Nada, Bryaune Carter, Zahoor A. Shah, L.M. Viranga Tillekeratne,