Synthesis and in vitro cytotoxic activity evaluation of novel heterocycle bridged carbothioamide type isosteviol derivatives as antitumor agents

Two series of novel carbothioamide-substituted pyrazole and isoxazolidine derivatives were facilely prepared. Within all compounds, 12p (IC50 = 6.51 μM) showed the highest cytotoxic activity against Raji cell.