Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA

The docking poses of the alkylides 17, 18, 19 and 20 overlapped with the crystal structure of clarithromycin. Our molecular modeling results for 17-20 shed light on the reason why the sidechains' conformational flexibility at the 3-O position has a significant impact on their antibacterial activity.