کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10588139 | 981449 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and cytotoxic activity of non-naturally substituted 4-oxycoumarin derivatives
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
From a series of 12 synthesized diversely substituted 4-oxycoumarin derivatives the most potent bioactive molecule as anti-proliferative on breast adenocarcinoma cells (MCF-7), human promyelocytic leukemia cells (HL-60), human histiocytic lymphoma cells (U937) and mouse neuroblastoms cells (Neuro2a) was the 4-hydroxy-5,7-dimethoxycoumarin (compound 1). It showed similar potency in all cancer cell lines tested, with IC50 = 0.2-2 μM, higher than tamoxifen (IC50 = 8-14 μM) and coumarin (IC50 = >50 μM) used as positive controls. Intriguingly its structural isomer, compound 2, in which only one methoxy group is changed from 5 to 8 position, is not active in MCF-7 cells, while it is weakly active in HL-60, U937 and Neuro2a cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 18, 15 September 2012, Pages 5791-5794
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 18, 15 September 2012, Pages 5791-5794
نویسندگان
Silvia Serra, Andrea Chicca, Giovanna Delogu, Saleta Vázquez-RodrÃguez, Lourdes Santana, Eugenio Uriarte, Laura Casu, Jürg Gertsch,