کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10588514 981474 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines
چکیده انگلیسی
A set of nine new arylpyrrolyl derivatives of 7-chloro-4-aminoquinoline, characterized by different substituents on the phenyl ring or different distance between the pyrrolic nitrogen and the 4-aminoquinoline, has been synthesized and tested for their activity against D-10 (CQ-S) and W-2 (CQ-R) strains of Plasmodium falciparum. All compounds exhibited activity against the CQ-S strain in the low nM range, comparable to that of chloroquine. Some of them were also highly active against the CQ-R strain and not toxic against normal cells. The antimalarial activity of this new class of compounds seems to be related to the inhibition of heme detoxification process of parasites, as in the case of chloroquine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 18, 15 September 2010, Pages 6625-6633
نویسندگان
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