کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10588818 | 981505 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus](/preview/png/10588818.png)
چکیده انگلیسی
Novel S-aryltriazole acyclonucleosides were designed as structural analogs based on the previously identified antiviral aryltriazole acyclonucleosides in our laboratories. These S-aryltriazole nucleosides were synthesized in excellent yields via SNAr-mediated S-arylation, followed by subsequent ammonolysis. X-ray structural analysis revealed special structural feature brought by the S-linkage, which may represent an unfavorable factor contributing to the lack of anti-HCV activity for this family of triazole nucleosides.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 12, 15 June 2010, Pages 3610-3613
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 12, 15 June 2010, Pages 3610-3613
نویسندگان
Yang Liu, Yi Xia, Wei Li, Mei Cong, Alain Maggiani, Pieter Leyssen, Fanqi Qu, Johan Neyts, Ling Peng,