کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10588829 981505 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tricyclic sulfones as orally active γ-secretase inhibitors: Synthesis and structure-activity relationship studies
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Tricyclic sulfones as orally active γ-secretase inhibitors: Synthesis and structure-activity relationship studies
چکیده انگلیسی
Tricyclic sulfones were designed as γ-secretase inhibitors and found to have excellent potency. Extensive SAR shows that a large number of sulfonamides at position 7 of the tricycle are very well tolerated. Compounds such as 15a and 15c showed remarkable in vivo potency.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 12, 15 June 2010, Pages 3632-3635
نویسندگان
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