Synthesis and structure-activity relationships of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives as a novel class of NCX inhibitors: a QSAR study

A series of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives were prepared, and their inhibitory activities against the reverse and forward modes of the sodium-calcium exchanger were evaluated. The structure-activity relationships for these compounds are discussed, and the results of a QSAR study are presented.