Synthesis and structure-activity relationships of benzyloxyphenyl derivatives as a novel class of NCX inhibitors: effects on heart failure

A series of benzyloxyphenyl derivatives were prepared, and their inhibitory activities against the reverse and forward modes of the sodium-calcium exchanger (NCX) were evaluated. The structure-activity relationships of these compounds are discussed. 6-{4-[(3-Fluorobenzyl)oxy]phenoxy}-N-(pyridin-4-ylmethyl)nicotinamide was further evaluated for its effects in a heart failure model.