QSAR analyses on ginkgolides and their analogues using CoMFA, CoMSIA, and HQSAR

QSAR study was carried out on 117 ginkgolide analogues using the methods of CoMFA, CoMSIA, and HQSAR, for finding new potent substitutes of the natural ginkgolides for treating PAF related diseases. The possible binding mechanism between ginkgolides and human PAF receptor was also deduced based on the QSAR results.