Design, development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties

The bioconjugates having curcumin covalently attached to piperic acid, glycine, glycyl-piperic acid, alanine and acetic acid through its free phenolic groups show better antibacterial and antifungal activities via-à-vis curcumin against some common pathogenic microbes viz. Escherichia coli, Pseudomonas aeruginosa, Pseudomonas pyocynin, Candida krusei GO3 and Candida albicans (yeast). These activities have been found to be equivalent to that of the marketed drugs, Cefepime (antibacterial) and flucanozole (antifungal).