Cardioprotective activity of melatonin and its novel synthesized derivatives on doxorubicin-induced cardiotoxicity

The synthesis and the cardioprotective activity of some novel synthesized melatonin analogs against doxorubicin-induced cardiac toxicity in rats is investigated in comparison with the parent melatonin. Treatment with melatonin and its derivatives 3 and 10b could reduce the markers of oxidative stress and restore the activity of the antioxidative enzymes in the heart tissue. In conclusion, the cardioprotective effect of melatonin and its derivatives may be mediated through the antioxidant and free radical scavenging activity of these compounds. Compound 10b has the strongest antioxidant activity, which exceeds that of the parent reference, melatonin, followed by compound 3 then 9.